In the early history of Manitowoc County, Branch, originally named Lenaville, boasted many businesses and amusement places. Some of the earliest businesses included a shingle mill and logging camp, grist mill, brewery, two sawmills, and two blacksmith shops in the early 1850s.

The name change from Lenaville to Branch occurred in 1872 with the first train passing through. Railroad construction had previously been put on hold during the Civil War. The station was built in 1872. Seven passenger trains and a freight train passed through Branch daily.